| abstract |
A cell marker / specific ligand angiogenesis system in which a cell marker is present on the outer membrane of the cell. A cell marker / specific ligand angiogenesis system in which a cell marker is present on the outer membrane of the cell comprises: (a) a cell marker selected from Ephs (especially EphB4 or EphB1). An endothelial progenitor cell (EPC) composed of a marker, and (b) a protein substance represented by the structural formula: LK (I), comprising a ligand (L) specific for the marker And a cellular substance represented by the structural formula: EPC-Eph-LK (II), which is composed of a protein substance associated with or fused to the binding protein (K) and stimulates angiogenesis. The present invention also relates to the cellular material as a product that stimulates angiogenesis, a method for producing the same, and a therapeutic use thereof, particularly a therapeutic use for vascular insufficiency. [Selection] Figure 2 |