| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f26ef37b090e0db41ba60eb7a48d7180 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-245 |
| filingDate |
2014-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23a55a733deeea399145ce2324394301
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b873b88c71106bd6399943947bb8af68 |
| publicationDate |
2015-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2015057054-A |
| titleOfInvention |
Herpes simplex virus (HSV) with modified affinity, methods of use and preparation thereof |
| abstract |
The present invention provides modified herpes simplex virus (HSV), use of modified HSV in oncolytic virology, pharmaceutical preparations and methods of preparing modified HSV. A modified HSV comprising a glycoprotein envelope having a heterologous peptide ligand capable of binding under certain conditions to a given receptor that is expressed in diseased cells but not substantially expressed in non-affected cells, comprising: A modified HSV in which the glycoprotein envelope has been modified to reduce the ability of the modified HSV to interact with the receptor Nectin1 / HveC. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7204653-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11357847-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019044925-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020109389-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018323502-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2019044925-A1 |
| priorityDate |
2014-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |