Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f782ef3481702b4f20a10a824de3807d |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
filingDate |
2014-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2d7aebbf567356aa838e37529c468b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa441e304f64aad7b4b295c6901baca8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_601654fcf188beb13739f3ecc430db61 |
publicationDate |
2015-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2015034180-A |
titleOfInvention |
Compositions and methods for achieving sustained therapeutic drug concentrations in a subject |
abstract |
The present invention provides compositions and methods for achieving sustained therapeutic drug concentrations in a subject. Described herein are compounds and methods for achieving sustained therapeutic effects of small molecule anticancer agents upon in vivo administration. Provided herein are methods for achieving a metronomic dosing profile in vivo upon a single administration of a topoisomerase inhibitor prodrug. The method comprises administering a prodrug of a topoisomerase inhibitor, wherein the topoisomerase inhibitor is releasably linked to a polyethylene glycol moiety to a mammalian subject (such as a human), thereby providing a single dose. A plasma concentration of the topoisomerase inhibitor or metabolite thereof is maintained above the detection level for at least 7 days after administration. [Selection] Figure 1 |
priorityDate |
2008-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |