http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015033392-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate | 2014-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_590cc443536a933d9b471ea980a4a6ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f70cab12af0104a782865afefe43b13a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79f7bf74558f33e0237dd5e0ee62184a |
| publicationDate | 2015-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015033392-A |
| titleOfInvention | Protein surface remodeling |
| abstract | A system for routine modification is provided to make proteins more stable and / or to prevent aggregation. Aggregation is a major cause of poor protein behavior. Systems are provided for modifying proteins to produce more stable variants. The method involves identifying non-conserved hydrophobic amino acid residues on the protein surface that are suitable for mutating to more hydrophilic residues (eg, charged amino acids). Any number of residues on the surface are modified to produce variants that are more soluble, have a higher resistance to aggregation, have a higher refolding ability, and / or are more stable in various conditions There is a case. The present invention also provides GFP, streptavidin, and GST variants with high theoretical net charge produced by the techniques of the present invention. Also provided are kits for performing such modifications in any protein of interest. [Selection] Figure 1 |
| priorityDate | 2006-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 194.