| abstract |
Provided is a sublingually administrable vaccine composition that is useful as a preventive or therapeutic agent for infectious diseases and can effectively induce systemic immune response and mucosal immune response. A vaccine composition to be administered into the oral cavity of a human or animal, comprising at least one infectious disease-derived antigen, toll-like receptor 4 (TLR4) agonist, toll-like receptor 2/6 (TLR2) / 6) an agonist and at least one selected from the group consisting of cyclic bisdinucleotides or derivatives or salts thereof, the infectious disease-derived antigen is an influenza virus-derived antigen, and the influenza virus-derived antigen is A vaccine composition characterized by being a whole virus particle. [Selection figure] None |