| abstract |
Disclosed is a compound useful as an inhibitor of ATR protein kinase, which is involved in a cellular response to DNA damage. A pyrazine compound represented by the formula IA or a pharmaceutically acceptable salt thereof. (Ring A is oxadiazole, 5-membered heteroaryl ring thiadiazole, Y is C 1 - 10 aliphatic chain, O and up to three methylene units of the aliphatic chain, S, NR, C ( O), S (O) can換Ru placed in 2; J is H or C 1 - 4 alkyl; Q is a 5-6 membered containing N, O, 0-4 heteroatoms from among S R 5 is a 3-7 membered monocyclic, saturated, partially unsaturated or aromatic ring containing 0-4 heteroatoms out of N, O, S) [Selection figure] None |