http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015019617-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0669f10ac82c082c17a3bf9d4a941b96 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 2013-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e27ac3e1846d4a82ba6ba8488b2e4b96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9831012792222f93c171de2e7fdf571 |
| publicationDate | 2015-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015019617-A |
| titleOfInvention | Non-human mammal as a model animal for obstructive arteriosclerosis, a model animal for studying sputum, and a model animal for systemic amyloidosis |
| abstract | An animal model for obstructive arteriosclerosis, a model animal for studying thin drugs, and at least one disease model animal selected from the group of diseases consisting of systemic amyloidosis are provided. The invention is achieved by a non-human mammal characterized by causing endogenous IL-1α and / or IL-1β to cause at least one disease of the above-mentioned disease group. At this time, the non-human mammal is (1) a transgenic non-human mammal that has a recombinant DNA linked to the above-mentioned caspase 1 gene downstream of a gene promoter that is specifically expressed in the skin, and continuously causes dermatitis. Or (2) having recombinant DNA linked to a parathyroid hormone gene leader sequence and IL-18 gene downstream of a skin-specific gene promoter and secreting mature IL-18 continuously in the blood. A transgenic non-human mammal that continuously causes dermatitis is preferred. [Selection] Figure 6 |
| priorityDate | 2013-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 229.