abstract |
The use of an anti-connexin polynucleotide for the treatment of surgical adhesions. Connexin modulation and related methods, compositions, and articles for the treatment of surgical adhesions. The present invention provides a method of preventing or reducing post-operative adhesions in a subject, the method comprising administering an effective amount of an anti-connexin polynucleotide to a patient at the surgical site. In one embodiment, the anti-connexin polynucleotide is administered at the surgical incision site. In one embodiment, the anti-connexin polynucleotide is administered during and / or after surgery. In one embodiment, the anti-connexin polynucleotide (1) down-regulates connexin protein expression, (2) inhibits cell-cell communication by reducing gap junction formation, (3) surgical or surgical It is effective in whole or in part to prevent or reduce surgical adhesions at the site of repair. [Selection figure] None |