| abstract |
PROBLEM TO BE SOLVED: To provide a polymeric substance targeted and loaded with a drug at a high density. Polymeric delivery devices have been developed that combine high load / dense delivered molecules with targeting choices. As used herein, “high density” refers to microparticles having a high density of ligand or coupling agent, preferably 1,000 to 10 per square micron surface area of microparticles. A range of 1,000,000, more preferably between 10,000 and 1,000,000 ligands. Targeting molecules can also be bound to the surface of the polymer. Specificity is determined by the choice of this targeting molecule. This effect can also be adjusted by density and binding means, which may be covalent or ionic, direct or via a linker means. [Selection figure] None |