| abstract |
An object of the present invention is to provide novel pregnane and androstane steroids having allosteric GABA activity. The present invention relates to compounds of structures 1, 2, and 3 and stress, anxiety, mood disorders, epileptic seizures, relief of depression, drug and alcohol dependence, memory impairment, premenstrual tension syndrome, and The use of these compounds as allosteric modulators of the GABA receptor chloride ionophore complex for the treatment of nervous system injury is described. [Selection figure] None |