| abstract |
8 of formula (II) wherein one or two of X 1 , X 2 and X 3 are N, useful for inhibiting Btk kinase and treating immune disorders such as inflammation mediated by Btk kinase -Fluorophthalazin-1 (2h) -one compounds are provided, including stereoisomers, tautomers and pharmaceutically acceptable salts thereof. Disclosed are methods of using compounds of formula (II) for in vitro, in situ and in vivo diagnosis and treatment of such disorders or related pathological conditions in mammalian cells. |