| abstract |
The present invention provides methods and pharmaceutical compositions for treating disorders using treatment regimens involving multiple agents. In one aspect, a therapeutic method is provided that results in reduced toxicity and / or synergy by administration according to the described dosing schedule. A method of treating a neoplastic condition in a subject according to a regimen comprising administering to said subject a first agent and a second agent that is an mTor inhibitor, wherein the first and second agents comprise , Comprising at least one cycle of administration of 1, 2, 3, 4, 5, 6, 7, or 8 consecutive days of said first agent followed by at least 1 day of administration of said second agent; Also provided is a method wherein the regimen is administered according to a dosing schedule and the regimen produces a synergistic effect in treating the neoplastic condition. [Selection] Figure 1A |