| abstract |
Alkylations of formula I, including their stereoisomers, tautomers, and pharmaceutically acceptable salts, useful for the treatment of immune diseases such as inhibition of Btk kinase and inflammation mediated by Btk kinase Piperazine Compound I is provided. Disclosed are methods of using compounds of formula I for the treatment, in vitro, in situ, and in vivo diagnosis of such disorders in mammalian cells or related pathological conditions. |