abstract |
Disclosed are compounds of formula (I) that inhibit the activity of anti-apoptotic Bcl-xL protein, compositions comprising the compound, and methods for treating diseases in which Bcl-xL protein is expressed, such as cancer. X is heteroaryl; Y 1 is phenylene or heteroarylene; L 1 is a linking group; Y 2 is cycloalkyl, cycloalkenyl, heterocyclic alkyl or heterocyclic alkenyl; Z 1 is C (O ) OR 9 , C (O) NR 10 R 11 , C (O) R 11 , NR 10 C (O) R 11 and the like. |