| abstract |
The methods, systems, and devices disclosed herein generally include convective enhanced delivery of a drug to a target region within a patient. Microfluidic catheter devices are disclosed and these devices are particularly suitable for targeted delivery of drugs by convection, including devices capable of multi-directional drug delivery, fluid pressure using the Venturi effect And devices for controlling speed, and devices including compatible balloons. Methods for treating various diseases using such devices are also disclosed, including methods for treating spongiform malformations, cavernoma, and hemangioma of the brain and spinal cord, treating neurological diseases A method of treating using multiple microfluidic delivery devices, a method of treating hearing impairment, a method of delivering spinal drug using a microfluidic device, and a method of delivering stem cells and therapeutic substances during fetal surgery It is. A method of manufacturing such a device is also disclosed. |