| abstract |
Compounds of formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , and X 2 have the meaning given herein, as well as their stereoisomers and pharmaceutically acceptable Salts and solvates are inhibitors of one or more JAK kinases, autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues, and cells, as well as hematological disorders and malignancies and their It is useful for the treatment of comorbidities. The present invention relates to novel compounds, pharmaceutical compositions containing the compounds, processes for making the compounds, and the use of the compounds in therapy. [Selection figure] None |