| abstract |
The present invention relates to novel macrocyclic compounds that act as kinase inhibitors, in particular as inhibitors of LRRK2 (leucine-rich repeat kinase 2), and compositions containing the compounds. Furthermore, the present invention provides methods for the preparation of the disclosed compounds and for the treatment and / or diagnosis of diseases characterized by LRRK2 kinase activity, such as, for example, neurological disorders including, inter alia, Parkinson's disease and Alzheimer's disease. Methods for their use as pharmaceuticals or diagnostics are provided. |