| abstract |
Provided herein are methods and compositions for controlling assembly of modified viral core proteins into, for example, viral capsids or nanocages. In some embodiments, the disclosed modified viral core protein comprises at least one mutation or modification that can substantially prevent the assembly of the viral core protein until assembly is desired. In some embodiments, the assembly of viral core proteins can be actuated, for example, by contacting the viral core protein with a reducing agent and / or by reducing the concentration of denaturing agent. Viral core proteins can self-assemble to form viral capsids or nanocages. [Selection] Figure 1 |