| abstract |
The devices, methods, and computer program products disclosed herein include non-dissolved particles, such as, but not limited to, glass flakes and / or protein aggregates in a fluid in solution, such as a fluid containing a drug. Can be used for non-destructive detection. An apparatus for non-destructive detection of non-dissolved particles in a container that is at least partially filled with fluid is configured to obtain (a) time-series data representing the trajectory of particles in the fluid; An imaging device; (b) a memory operatively coupled to the imaging device and configured to store time series data; and (c) a processor operably coupled to the memory, wherein (i) Reversing the time order of the time series data to form reverse time series data, (ii) estimating the trajectory of the particles from the reverse time series data, and (iii) the presence or type of particles based on the trajectory And a processor configured to detect particles. |