abstract |
The present invention is directed to pyrimidine compounds useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds to treat neurological and psychiatric disorders such as schizophrenia, psychosis or Huntington's disease, and neurological and psychiatric disorders associated with striatal hypofunction or basal ganglia dysfunction. About. |