| abstract |
The present invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one antifungal or antibacterial agent and at least one linker and / or carrier. This prodrug has the following formula: (i) (AFA) m -X- (L) n , (ii) [(AFA) m ' -X] p -L, (iii) AFA- [X- (L ) N ′ ] q , or (iv) (AFA) m ″ -X, wherein AFA is an antifungal or antibacterial agent, L is a carrier, X is a linker, m is in the range of 1-10, n is in the range of 2-10, m ′ is 1-10, p is 1-10, n ′ is 1-10 , Q is 1 to 10, provided that q ′ and n are not 1 and m ″ is 1 to 10. The invention also provides nanoparticles comprising conjugate-based prodrugs. In addition, the present invention provides unconjugated antifungal and antibacterial agents in the form of nanoparticles. |