| abstract |
The present application is a taste masked multilayer particle comprising a pharmaceutically active ingredient, comprising: (a) an inert core; (b) one or more coating layers comprising a pharmaceutically active ingredient and a binder; and (c) An intermediate coating layer (seal coating) comprising a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG, or (ii) PVP, but free of low molecular weight water-soluble ionic compounds; (d) Comprising a mixture comprising (i) poly (meth) acrylate, or (ii) 60-90% (w / w) EC and 10-40% (w / w) HPMC, but with low molecular weight water soluble ionicity And an outer coating layer (final or taste masking coating) free of the compound, wherein the pharmaceutically active ingredient is water soluble and at least one basic group and / or bitter Including any of the relates to a multilayer particles masking the taste. Further disclosed are methods for producing such particles and pharmaceutical compositions containing them. |