| abstract |
Provided are methods and compositions for treating an inflammatory or autoimmune disease in a subject comprising blocking the interaction between DR3 and TL1A. The interaction between DR3 and TL1A can be blocked by decreasing the expression of TL1A. The interaction between DR3 and TL1A can be blocked by administration of anti-DR3 antibody. The interaction between DR3 and TL1A can be blocked by administration of anti-TL1A antibody. In the method of treating an inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component. In a method of treating an inflammatory or autoimmune disease, the inflammatory or autoimmune disease is asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft-versus-host disease or inflammatory bowel disease (IBD) Can be. [Selection figure] None |