| abstract |
This embodiment provides a prodrug compound of Formula I-Formula XVII. The present disclosure also provides compositions, and methods of use thereof, wherein the composition comprises a prodrug compound of Formula I-Formula XVII that provides controlled release of the active agent. The composition can optionally provide a trypsin inhibitor that interacts with an enzyme that mediates controlled release of the active agent from the prodrug to attenuate enzymatic cleavage of the prodrug. [Selection figure] None |