abstract |
The present invention encompasses compounds that modulate the activity of the Epstein-Barr Nuclear Antigen 1 (EBNA1) protein and their use in methods of treating latent Epstein-Barr virus infection. R 7 is a substituted or unsubstituted phenyl, pyridyl, or pyrimidinyl group. Also provided is a pharmaceutical composition comprising a compound of the present invention in admixture with a pharmaceutically acceptable carrier, wherein the composition of the present invention modulates the activity of Epstein-Barr Nuclear Antigen 1 (EBNA1) protein, and latent Epstein -Also provided as a method of treating bar virus infection. |