Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6415 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0205 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
filingDate |
2012-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2014-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2014515735-A |
titleOfInvention |
N carboxyalkyl auristatin and uses thereof |
abstract |
The present application relates to novel derivatives of monomethyl auristatin E and monomethyl auristatin F substituted on the N-terminus by a carboxyalkyl group, methods for preparing these derivatives, these derivatives for treating and / or preventing diseases. The use of these derivatives for the manufacture of a medicament for the treatment and / or prevention of hyperproliferative and / or angiogenic disorders such as, for example, cancer disorders. Such treatment can be given as a single agent therapy or in combination with other medications or other therapeutic means. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014512375-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014515753-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016175941-A |
priorityDate |
2011-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |