| abstract |
A compound of the formula I, wherein R 6 is CN, ethenyl, 2-haloethen-1-yl, or (C 2 -C 8 ) -alkyn-1-yl, a nucleoside, nucleoside thereof Phosphoric acid and prodrugs are provided. The provided compounds, compositions and methods are useful for the treatment of Flaviviridae viral infections. Compounds that inhibit Flaviviridae viruses are provided. The invention also includes compounds of formula I that inhibit viral nucleic acid polymerases, specifically HCV RNA-dependent RNA polymerase (RdRp), rather than cellular nucleic acid polymerases. [Selection figure] None |