| abstract |
The present disclosure provides tyrosine kinases, particularly BLK, BMX, EGFR, HER2, HER4, ITK, JAK3, TEC, Btk, and TXK inhibitors, and thus diseases that can be treated by inhibition of tyrosine kinases, such as cancer and inflammatory diseases, Compounds and pharmaceutically acceptable salts are provided that are useful in the treatment of, for example, arthritis. Also provided are pharmaceutical compositions comprising such compounds and pharmaceutically acceptable salts and methods of preparing such compounds and pharmaceutically acceptable salts. |