| abstract |
The present invention relates to a phosphatidylinositol-3-kinase (PI3K) inhibitory compound that is a 2-carboxamide cycloaminourea derivative or a pharmaceutically acceptable salt thereof and at least one mammalian rapamycin target protein (mTOR) inhibitor or pharmaceutically Pharmaceutical combinations comprising acceptable salts thereof, pharmaceutical compositions comprising such combinations and proliferative diseases, more particularly such combinations for the treatment of mammalian rapamycin target protein (mTOR) kinase dependent diseases About the use of. |