| abstract |
Disclosed are compounds of formula (I) or prodrugs thereof; (Where R 1 is —CH 2 CF 3 or —CH 2 CH 2 CF 3 ; R 2 is —CH 2 CF 3 , —CH 2 CH 2 CF 3 , or —CH 2 CH 2 CH 2 CF 3 R 3 is H or —CH 3 ; each R a is independently F, Cl, —CN, —OCH 3 , and / or —NHCH 2 CH 2 OCH 3 ; and z Is 0, 1, or 2. Also disclosed are methods of using the compounds to inhibit Notch receptors, as well as pharmaceutical compositions containing the compounds. These compounds are useful in treating, preventing, or delaying progression of a disease or disorder in various therapeutic areas (eg, cancer). |