http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014510789-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2012-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2014510789-A |
| titleOfInvention | Methods for suppressing allograft rejection |
| abstract | Disclosed herein are methods for treating or suppressing allograft rejection in a transplant recipient. In some embodiments, the method comprises a first amount of 5- (2- (4-fluoro-3-methoxy-5-methylphenylamino) -5-methylpyrimidin-4-ylamino) benzo [d] Administering a JAK1 / 3 inhibitor comprising an oxazol-2 (3H) -one (compound I) or a prodrug thereof to the transplant recipient, and providing the transplant recipient with a second amount of non-JAK1 / 3 inhibitory immunity Administering the inhibitor, wherein the combined effect of the first amount and the second amount is greater than the effect of the first amount or the second amount individually, and the JAK1 / 3 inhibitor is Acts in combination with non-JAK1 / 3 inhibitory immunosuppressants to suppress or treat allograft rejection. In some embodiments, at least one of the first amount or the second amount is a suboptimal dose for individually inhibiting or treating allograft rejection. In some examples, the combined effect of the first amount and the second amount to suppress or treat allograft rejection in the transplant recipient is synergistic. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020096371-A1 |
| priorityDate | 2011-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 593.