| abstract |
The present invention relates to a method for treating bacterial infections that finds utility, for example in the treatment of infectious ulcers, optionally infectious diabetic ulcers. In particular, the present invention relates to bacteria by local administration of at least one aminoglycoside antibiotic at the site of infection, in combination with at least one antimicrobial agent administered remotely from the site of infection, preferably administered systemically. It relates to the treatment of infections such as infectious diabetic ulcers. In certain embodiments, the present invention provides a composition for use in the treatment of bacterial infection, wherein at least one gentamicin sulfate (water soluble broad aminoglycoside antibiotic) uniformly dispersed in a type I collagen matrix. In combination with a systemically administered antimicrobial agent. The present invention provides bactericidal activity against most strains of aerobic gram negative and gram positive pathogens, including facultative anaerobic gram negative pathogens, including methicillin resistant S. aureus. |