| abstract |
Provided are carboxylic acid ester derivatives of formula I, methods for their preparation, and methods of use thereof. These compounds are prodrugs of D-isoglutamyl- [D / L] -tryptophan. In vitro biochemical conversion to the prodrug parent drug D-isoglutamyl-D-tryptophan (or thymodepressin) was verified in human hepatocytes as well as in human blood. In vivo pharmacokinetics have also been reported following oral administration of several prodrugs to rats. [Chemical 1] |