| abstract |
The present invention relates generally to oligomers useful for modulating the expression and / or activity of RNA or genes. More particularly, the present invention relates to single-stranded, double-stranded, partially double-stranded, and hairpin structural chemistry having a broad biodistribution profile to inhibit RNA expression in multiple cells, tissues, or organs. It relates to modified oligomers as well as methods for making and using modified oligomers. In one embodiment, a method is provided for providing an oligomer to a plurality of cell types, tissues, or organs, the method comprising administering to the subject an oligomer comprising one or more minor groove binding components (MGB). Including. |