| abstract |
The present invention provides for the prevention, treatment or amelioration of a disease or condition responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release, or responsive to induction of necrosis. A compound of the general formula I, used alone or in combination with one or more other therapeutically pharmaceutically active compounds: [Wherein R is aryl substituted by R 3; or R is (C 3 -C 13 ) -cycloalkyl, (C 3 -C 13 ) -cycloalkenyl, optionally substituted by R 4, or (C 7 -C 13) - compound of a cycloalkynyl] or a pharmaceutically acceptable salt, hydrates or solvate thereof. |