| abstract |
With respect to diagnostic methods, treatment-related methods, or prognostic methods, biomarkers can be evaluated to identify a phenotype such as a disease state or disease, or disease stage or progression. Circulating biomarkers can be detected and optionally used for profiling physiological conditions or determining phenotypes. These include circulating structures such as nucleic acids, proteins, and vesicles. The biomarker can be evaluated for diagnostic, prognostic, or theranosis purposes, for example, to select candidate treatment regimens for the disease, condition, stage, and stage of the condition, and It can also be used to determine the therapeutic effect. Examples of useful circulating biomarkers include polypeptides, nucleic acids (eg, DNA, mRNA, microRNA), and vesicles. |