| abstract |
Disclosed are methods for searching, identifying or confirming the tumor-causing cell marker CACNA2D1. The method includes the step of immunizing the animal with HEP-12 cells rich in source cells derived from recurrent tumors. Also disclosed are monoclonal antibodies or antigen-binding fragments thereof that specifically recognize CACNA2D1, and their use to treat or prevent tumors or diseases or conditions associated with CACNA2D1. [Selection figure] None |