| abstract |
Hydrogenated pyrido [4,3-b] indole, pyrido [3,4-b] indole and azepino [4,5-b] indole are described. These compounds can bind to adrenergic receptor alpha 2B, and may be antagonists of adrenergic receptor alpha 2B. These compounds may also antagonize obtained, and the adrenergic receptor alpha 1B bonded to adrenergic receptor alpha 1B. The compounds may be useful, for example, in therapy to reduce (i) blood pressure and / or (ii) promote renal blood flow and / or (iii) reduce or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are responsive to, or expected to be responsive to, blood pressure reduction. Special mention is made of the use of compounds to treat cardiovascular and renal disorders. |