http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014504865-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2012-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2014504865-A |
| titleOfInvention | Nucleic acid molecule having binding affinity for target molecule and method for producing the same |
| abstract | The present invention provides a method for producing a nucleic acid molecule capable of binding to a target molecule, comprising the following steps: a) providing a reference nucleic acid molecule (wherein the reference nucleic acid molecule can bind to the target molecule; A reference nucleic acid molecule comprises a single nucleotide sequence, said nucleotide sequence comprising n nucleotides); b) preparing a first level derivative of said reference nucleic acid molecule, wherein said first number of said reference nucleic acid molecule A primary level derivative differs from the reference nucleic acid molecule at one nucleotide position, and the first level derivative, when the reference nucleic acid molecule has a ribonucleotide at a certain nucleotide position, converts the ribonucleotide at that nucleotide position to 2′- Prepared by replacing with deoxyribonucleotides, and the first level derivative is a nucleoside containing the reference nucleic acid. If it has a 2′-deoxyribonucleotide at the tide position, the nucleotide position prepared by replacing the 2′-deoxyribonucleotide at that nucleotide position with a ribonucleotide, and where the replacement is made is a modified nucleotide position); and c) Repeating step b) for each nucleotide position of the reference nucleic acid molecule, thus preparing a group of first level derivatives of the reference nucleic acid molecule, wherein the first level derivative of the reference nucleic acid molecule The group consists of n first level derivatives, each of the first level derivatives of the reference nucleic acid molecule differing from the reference nucleic acid molecule by a single nucleotide substitution, and the first of the reference nucleic acid molecules Each of the level derivatives is a first level derivative of the reference nucleic acid molecule. Regarding a method comprising all the single modified nucleotides different with a single modified nucleotide position) of a single modified nucleotide position of the other primary level derivatives. [Selection figure] None |
| priorityDate | 2011-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 280.