| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1611
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1617
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1688
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1629 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate |
2011-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2014504260-A |
| titleOfInvention |
Aggregated nanoparticulate drug formulation, its manufacture and use |
| abstract |
A method of making aggregate particles suitable for a powder aerosol composition comprising: (a) forming a dispersion of nanoparticulate drug particles and / or nanoparticulate excipient particles in a non-aqueous liquid, wherein The drug particles and / or the excipient particles have a solubility of less than 10 mg / mL in the liquid dispersion medium; the nanoparticulate drug particles have a preselected crystalline form And when the nanoparticles dispersed in the dispersion do not contain excipients, the non-aqueous liquid does not have a suspension homogenizing surfactant dissolved therein); (b) Spray-drying the dispersion of nanoparticulate drug particles and / or nanoparticulate excipient particles to produce aggregate particles containing nanoparticulate drug particles and / or nanoparticulate excipient particles (Wherein the nanoparticles of the drug and / or excipient maintain their preselected crystalline form and the aggregated particles have a median aerodynamic mass of about 100 microns or less. And when the nanoparticles dispersed in the dispersion are free of excipients, the aggregated particles are substantially free of a homogenizing surfactant). As well as pharmaceutical compositions thereof. [Selection] Figure 1 |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016510742-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013082660-A |
| priorityDate |
2010-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |