| abstract |
The present invention provides inter alia heteroarylsulfonamide derivatives as blockers of Kv potassium channels, and more particularly channels Kv1.5, Kv4.3 or Kv11.1, their application in clinical therapy and methods for their production. About. These compounds have the general formula (I) below, wherein R1 is hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C 1 -C 4 alkyl, or linear or branched C 1 or more substituents of the phenyl core X, such as 1 -C 4 alkoxy, A represents oxygen or sulfur, n = 1 or 2, and D represents -C (= O)- , B represents nitrogen, or when n = 0 and D represents —CH 2 O—, or when n = 1 and D represents —O—, B represents CH, R 2 Represents a hydrogen, methyl, fluorine or chlorine atom, or methoxy, and HetAr is a group such as linear or branched C 1 -C 4 alkyl, linear or branched C 1 -C 4 alkoxy, halogen or trifluoromethyl In some cases Have been conversion corresponds to also represent a pyridyl or quinolyl group), corresponding to their pharmaceutically acceptable salts. |