| abstract |
Stents or other implantable medical devices for local delivery of selective adenosine receptor agonists can be used in combination with other therapeutic agents to reduce myocardial injury after acute myocardial infarction. As soon as possible after acute myocardial infarction, a stent or other suitable device that contains and can deliver a selective adenosine receptor agonist into a vessel with an occlusion that causes the infarction. Position. When positioned in place, the stent or other endoluminal device deploys, removes the occlusion, and restores blood flow to a specific site, region, or tissue volume of the heart. Over a specified period of time, selective adenosine receptor agonists, either alone or in combination with other therapeutic agents, are downstream from the stent or other device for a time sufficient to reduce the extent of myocardial injury. And elutes into hypoxic heart tissue. |