abstract |
The present invention modulates the activity of Janus kinase (JAK) and is useful in the treatment of diseases associated with the activity of JAK, including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases. Provided are cyclobutyl-substituted pyrrolopyrimidines and pyrrolopyridines of the formula (wherein X, Y, Z, L, A, R 5 , n, and m are defined above), and compositions and methods of use thereof. |