| abstract |
Disclosed is a compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6). [Effect] The compound of the present invention represented by the general formula (I), a salt thereof, a solvate thereof, or a prodrug thereof is capable of binding to an S1P receptor (especially EDG-6, preferably EDG-1 and EDG-6). It is useful for prevention and / or treatment of transplant rejection, graft-versus-host disease, autoimmune disease, allergic disease and the like. Wherein ring A is a cyclic group; ring B is an optionally substituted cyclic group; X is a spacer having 1 to 8 atoms in the main chain; Y is an atom having 1 to 10 atoms in the main chain Spacer, etc .; n is 0, 1; when n is 0, m is 1, and R 1 is a hydrogen atom and a substituent; when n is 1, m is an integer of 0, 1 to 7 , and R 1 is substituted And R 1 may be the same or different when m is 2 or more). [Selection figure] None |