abstract |
A novel peroxisome proliferator activated receptor (PPAR) modulator is provided. Specific 1,3-dioxane derivatives. Preferably, the compound represented by formula XI. [X is F, Cl, Br, trifluoromethyl, substituted phenyl, cyano, methoxy, nitro, hydroxyl and H; Y is F, Cl, Br, trifluoromethyl, substituted phenyl, cyano, methoxy, nitro, hydroxyl , -C (O) -saccharide and H; Rd is -NH-C1-6-alkyl (branched or linear, preferably linear), -O-C1-6-alkyl (branched or linear, preferably Is linear), sugar or OH] [Effects] The compound is effective for metabolic syndrome, obesity, insulin resistance, diabetes, dyslipidemia, autoimmune disease, psoriasis, atopic dermatitis, asthma and ulcerative colitis, cancer and the like. [Selection figure] None |