| abstract |
Bioavailability of suberoylanilide hydroxamic acid (SAHA), which is a histone deacetylase inhibitor that selectively induces terminal differentiation, neoplastic cell proliferation and / or apoptosis of neoplastic cells and is effective against cancer. Providing a method for producing high-crystals. A method for producing SAHA in a crystalline form represented by the following formula. (A) a step of reacting suberic acid with aniline to produce suberanilic acid or a salt thereof; (b) a step of reacting suberanilic acid or a salt thereof with methanol to produce methyl suberanilic acid; A method for producing SAHA in a crystalline form, comprising the step of reacting methyl anilate with hydroxyamine hydrochloride to produce crude SAHA, and (d) recrystallizing the crude product of SAHA from a mixture of methanol and water. [Selection figure] None |