| abstract |
【Task】 Provided is a compound useful as an active ingredient of a pharmaceutical composition for the treatment of diseases involving RANKL / RANK signals such as osteoporosis, osteopenia and rheumatoid arthritis. [Solution] The present inventors examined a compound having RANKL / RANK signal inhibitory activity, and that 2- (pyridin-2-yl) pyrimidin-4-amine compound or a salt thereof has potent RANKL / RANK signal inhibitory activity, It was confirmed that the RANKL-induced bone mineral loss was improved and effective in an osteoporosis model, and the present invention was completed. The 2- (pyridin-2-yl) pyrimidin-4-amine compound of the present invention or a salt thereof has RANKL / RANK signal inhibitory activity, and diseases involving RANKL / RANK signals such as osteoporosis, osteopenia, rheumatoid arthritis, etc. It can be used as a therapeutic agent. [Selection figure] None |