abstract |
An object of the present invention is to provide a preparation method for preparing β-hematin crystals through a heating step, β-hematin crystals obtained by the preparation method, and a vaccine adjuvant composition containing the β-hematin crystals. SOLUTION: It has a needle-like morphology, an average particle diameter of 0.6 to 1.2 μm, and in X-ray diffraction obtained by powder X-ray diffraction with Cu-Kα rays, it is 7.4 ?, 12.2 ?, 21.6? And 24.1? A β-hematin crystal having a characteristic main peak with a diffraction angle 2θ (each peak includes a diffraction angle of? 0.2?). [Selection figure] None |