| abstract |
[PROBLEMS] To stabilize an immunogenic composition against silicone-induced aggregation of a polysaccharide-protein conjugate contained in a silicone-treated container (silicone oil interaction), shear force, agitation during transportation, and the like. And providing a preparation that inhibits the precipitation. A pH buffered salt solution which is a phosphate, succinate, histidine or citrate having a pKa of about 3.5 to about 7.5; aluminum which is aluminum hydroxide, aluminum phosphate or aluminum sulfate A formulation comprising a salt; and one or more polysaccharide-protein conjugates (eg, pneumococcal polysaccharide). [Selection figure] None |