| abstract |
The present invention provides novel methods and materials for preventing, reducing or treating edema of various etiologies. An isolated, substantially purified oligonucleotide compound comprising a specific sequence that is effective in reducing swelling and edema. The oligonucleotide compound is one of modulating vascular permeability, inhibiting or reducing leukocyte migration, inhibiting or reducing neutrophil migration or activation, inhibiting or reducing eosinophil migration, and inhibiting or reducing lymphocyte migration. Administered in an amount and form effective to achieve. An oligonucleotide in which at least one oligonucleotide is chemically modified with a phosphate backbone modification. [Selection] Figure 1 |